Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei

Abstract Background Vacuolar H+-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles. Beyond its role in pH maintenance, the involvement of V-ATPase in endocytosis is well documented in mammals and plants but is less clear in Try...

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Bibliographic Details
Main Authors: Zhi-Shen Xu, Feng-Jun Li, Geoff Hide, Zhao-Rong Lun, De-Hua Lai
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Parasites & Vectors
Subjects:
Trypanosoma brucei
Vacuolar ATPase
Apolipoprotein L1
Endocytosis
Trypanolysis
Online Access:http://link.springer.com/article/10.1186/s13071-020-04068-4

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http://link.springer.com/article/10.1186/s13071-020-04068-4

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