Modeling of xenobiotic transport and metabolism in virtual hepatic lobule models.

Computational models of normal liver function and xenobiotic induced liver damage are increasingly being used to interpret in vitro and in vivo data and as an approach to the de novo prediction of the liver's response to xenobiotics. The microdosimetry (dose at the level of individual cells) of...

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Bibliographic Details
Main Authors: Xiao Fu, James P Sluka, Sherry G Clendenon, Kenneth W Dunn, Zemin Wang, James E Klaunig, James A Glazier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6136710?pdf=render