Evaluation and validation of next-generation sequencing to support lot release for a novel type 2 oral poliovirus vaccine

Evaluation and validation of next-generation sequencing to support lot release for a novel type 2 oral poliovirus vaccine

A novel, genetically-stabilized type 2 oral polio vaccine (nOPV2), developed to assist in the global polio eradication program, was recently the first-ever vaccine granted Emergency Use Listing by the WHO. Lot release tests for this vaccine included—for the first time to our knowledge—the assessment...

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Bibliographic Details
Main Authors: John O. Konz, Tim Schofield, Sarah Carlyle, Rahnuma Wahid, Azeem Ansari, Jeroen R.P.M. Strating, Ming Te Yeh, Hasmik Manukyan, Saskia L. Smits, Erman Tritama, Latri Rahmah, Dori Ugiyadi, Raul Andino, Majid Laassri, Konstantin Chumakov, Andrew Macadam
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Vaccine: X
Subjects:
Next-generation sequencing
Validation
Poliovirus
OPV
Neurovirulence
Online Access:http://www.sciencedirect.com/science/article/pii/S259013622100019X

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http://www.sciencedirect.com/science/article/pii/S259013622100019X

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