FMRP regulates presynaptic localization of neuronal voltage gated calcium channels

FMRP regulates presynaptic localization of neuronal voltage gated calcium channels

Fragile X syndrome (FXS), the most common form of inherited intellectual disability and autism, results from the loss of fragile X mental retardation protein (FMRP). We have recently identified a direct interaction of FMRP with voltage-gated Ca2+ channels that modulates neurotransmitter release. In...

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Bibliographic Details
Main Authors: Laurent Ferron, Cesare G. Novazzi, Kjara S. Pilch, Cristian Moreno, Krishma Ramgoolam, Annette C. Dolphin
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Neurobiology of Disease
Subjects:
Calcium transients
Voltage-gated calcium channels
Trafficking
Synaptic transmission
Fragile X syndrome - FMRP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120300541

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http://www.sciencedirect.com/science/article/pii/S0969996120300541

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