CDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors

CDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors

Cyclin-dependent kinases (CDK) 4/6 inhibitors, namely abemaciclib, palbociclib, and ribociclib, interfere with cell cycle progression, induce cell senescence and might promote cancer cell disruption by a cytotoxic T cells-mediated effect. Phase III randomized clinical trials have proven that CDK4/6...

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Bibliographic Details
Main Authors: Francesco Schettini, Irene De Santo, Carmen G. Rea, Pietro De Placido, Luigi Formisano, Mario Giuliano, Grazia Arpino, Michelino De Laurentiis, Fabio Puglisi, Sabino De Placido, Lucia Del Mastro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
solid tumors
cyclin-dependent kinases
palbociclib
ribociclib
abemaciclib
cell cycle
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00608/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00608/full

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