DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

Abstract Two missense mutations of the DYRK1B gene have recently been found to co-segregate with a rare autosomal-dominant form of metabolic syndrome. This gene encodes a member of the DYRK family of protein kinases, which depend on tyrosine autophosphorylation to acquire the catalytically active co...

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Bibliographic Details
Main Authors: Samira Abu Jhaisha, Esti W. Widowati, Isao Kii, Rie Sonamoto, Stefan Knapp, Chrisovalantis Papadopoulos, Walter Becker
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06874-w

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https://doi.org/10.1038/s41598-017-06874-w

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