Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

Metabotropic glutamate receptors (mGluRs) are class C, synaptic G-protein-coupled receptors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form constitutive dimers. Despite the existence of a detailed picture of inter-LBD conformational dynamics and structural snapshots o...

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Bibliographic Details
Main Authors: Vanessa A Gutzeit, Jordana Thibado, Daniel Starer Stor, Zhou Zhou, Scott C Blanchard, Olaf S Andersen, Joshua Levitz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
GPCRs
glutamate receptor
conformational dynamics
Online Access:https://elifesciences.org/articles/45116

Internet

https://elifesciences.org/articles/45116

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