Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis

Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis

The energetically demanding process of translation is linked to multiple signaling events through mTOR-mediated regulation of eukaryotic initiation factor (eIF)4F complex assembly. Disrupting mTOR constraints on eIF4F activity can be oncogenic and alter chemotherapy response, making eIF4F an attrac...

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Bibliographic Details
Main Authors: Chen-Ju Lin, Zeina Nasr, Prem K. Premsrirut, John A. Porco, Jr., Yoshitaka Hippo, Scott W. Lowe, Jerry Pelletier
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712000678

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http://www.sciencedirect.com/science/article/pii/S2211124712000678

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