Role of Vitamin K-dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

Role of Vitamin K-dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of receptor tyrosine kinases (RTK), are key regulators of inflammation and vascular response to damage. TAM signaling, which has lar...

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Bibliographic Details
Main Authors: Anna Tutusaus, Montserrat Marí, José T. Ortiz-Pérez, Gerry A.F. Nicolaes, Albert Morales, Pablo García de Frutos
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
AXL
MERTK
GAS6
viral infection
coagulation
endothelium
Online Access:https://www.mdpi.com/2073-4409/9/10/2186

Internet

https://www.mdpi.com/2073-4409/9/10/2186

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