Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Secreted factors are a key component of stem cell niche and their dysregulation compromises stem cell function. Legumain is a secreted cysteine protease involved in diverse biological processes. Here, we demonstrate that legumain regulates lineage commitment of human bone marrow stromal cells and th...

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Bibliographic Details
Main Authors: Abbas Jafari, Diyako Qanie, Thomas L. Andersen, Yuxi Zhang, Li Chen, Benno Postert, Stuart Parsons, Nicholas Ditzel, Sundeep Khosla, Harald Thidemann Johansen, Per Kjærsgaard-Andersen, Jean-Marie Delaisse, Basem M. Abdallah, Daniel Hesselson, Rigmor Solberg, Moustapha Kassem
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Stem Cell Reports
Subjects:
legumain
bone marrow stromal cells
differentiation
proliferation
osteoblast
adipocyte
osteoporosis
mesenchymal stem cell
extracellular matrix
fibronectin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117300188

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http://www.sciencedirect.com/science/article/pii/S2213671117300188

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