Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM,...

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Bibliographic Details
Main Authors: Amanda de Melo Bezerra, Antônio Cláudio da Silva Lins, Petrônio Filgueiras de Athayde-Filho, Marcelo Sobral da Silva, José Maria Barbosa-Filho, Celso Amorim Camara, Tania Maria Sarmento Silva, Vanessa da Silva Luna, Creusioni Figueredo dos Santos
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
Licaria
lignoids
topoisomerase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100024&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100024&lng=en&tlng=en

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