Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes

Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes

Sublytic levels of C5b-9 increase the survival of oligodendrocytes (OLGs) and induce the cell cycle. We have previously observed that SIRT1 co-localizes with surviving OLGs in multiple sclerosis (MS) plaques, but it is not yet known whether SIRT1 is involved in OLGs survival after exposure to sublyt...

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Bibliographic Details
Main Authors: Alexandru Tatomir, Gautam Rao, Dallas Boodhoo, Sonia I. Vlaicu, Austin Beltrand, Freidrich Anselmo, Violeta Rus, Horea Rus
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
C5b-9
oligodendrocyte
SIRT1
cell cycle
cyclin D1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00619/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00619/full

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