Highly Efficient Biosynthesis of Glycyrrhetinic Acid Glucosides by Coupling of Microbial Glycosyltransferase to Plant Sucrose Synthase

Highly Efficient Biosynthesis of Glycyrrhetinic Acid Glucosides by Coupling of Microbial Glycosyltransferase to Plant Sucrose Synthase

Glycyrrhetinic acid (GA) is a principal bioactive pentacyclic triterpenoid from Glycyrrhiza uralensis. Uridine diphosphate-dependent glycosyltransferases (UGTs) have been widely used to catalyze glycosylation of diverse nature products for the development of potential therapeutic compounds. In this...

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Bibliographic Details
Main Authors: Mohamed Yassin Ali, Qing Chang, Quande Yan, Zheng Qian, Xiang Guo, Kieran Thow, Jinhong Wu, Yong Zhang, Yan Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
glycosylation
glycyrrhetinic acid
UDP-glycosyltransferases
biocatalytic cascade
sucrose synthase
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.645079/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2021.645079/full

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