BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice

BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice

Large conductance calcium-activated potassium (BK) channels play a key role in the control of neuronal activity. Ethanol is a potent activator of BK channel gating, but how this action may impact ethanol drinking still remains poorly understood. Auxiliary β subunits are known to modulate ethanol-ind...

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Bibliographic Details
Main Authors: Max eKreifeldt, David eLe, Steven N Treistman, George eKoob, Candice eContet
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Integrative Neuroscience
Subjects:
dependence
knockout mice
alcohol
two-bottle choice
vapor chambers
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00105/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00105/full

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