Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain

Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain

Abstract Background Neuroinflammation is a major driver of age-related brain degeneration and concomitant functional impairment. In patients with Alzheimer’s disease, the most common form of age-related dementia, factors that enhance neuroinflammation may exacerbate disease progression, in part by i...

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Bibliographic Details
Main Authors: Xiao-fei He, Li-li Li, Wen-biao Xian, Ming-yue Li, Li-ying Zhang, Jing-hui Xu, Zhong Pei, Hai-qing Zheng, Xi-quan Hu
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Neuroinflammation
Subjects:
Inflammatory bowel disease
Cognition
Glymphatic clearance
NLRP3 inflammasome
T cell
Online Access:https://doi.org/10.1186/s12974-021-02199-8

Internet

https://doi.org/10.1186/s12974-021-02199-8

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