PPAR-α Agonist Fenofibrate Prevented Diabetic Nephropathy by Inhibiting M1 Macrophages via Improving Endothelial Cell Function in db/db Mice

PPAR-α Agonist Fenofibrate Prevented Diabetic Nephropathy by Inhibiting M1 Macrophages via Improving Endothelial Cell Function in db/db Mice

Background: Diabetic nephropathy (DN) is one of the major diabetic microvascular complications, and macrophage polarization plays a key role in the development of DN. Endothelial cells regulate macrophage polarization. Peroxisome proliferator-activated receptor (PPAR)-α agonists were demonstrated to...

Full description

Bibliographic Details
Main Authors: Xiaomeng Feng, Xia Gao, Shuo Wang, Mengxiu Huang, Zhencheng Sun, Hengbei Dong, Haitian Yu, Guang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Medicine
Subjects:
PPAR-α agonists
diabetic nephropathy
macrophages
endothelial function
HIF-1α
Notch1
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.652558/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.652558/full

Similar Items