Thy-1 (CD90)-Induced Metastatic Cancer Cell Migration and Invasion Are β3 Integrin-Dependent and Involve a Ca2+/P2X7 Receptor Signaling Axis

Thy-1 (CD90)-Induced Metastatic Cancer Cell Migration and Invasion Are β3 Integrin-Dependent and Involve a Ca2+/P2X7 Receptor Signaling Axis

Cancer cell adhesion to the vascular endothelium is an important step in tumor metastasis. Thy-1 (CD90), a cell adhesion molecule expressed in activated endothelial cells, has been implicated in melanoma metastasis by binding to integrins present in cancer cells. However, the signaling pathway(s) tr...

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Bibliographic Details
Main Authors: Marianne Brenet, Samuel Martínez, Ramón Pérez-Nuñez, Leonardo A. Pérez, Pamela Contreras, Jorge Díaz, Ana María Avalos, Pascal Schneider, Andrew F. G. Quest, Lisette Leyton
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Thy-1 (CD90)
integrin
P2X7R
trans-endothelial migration
breast cancer
melanoma
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.592442/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.592442/full

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