Long Non-coding RNA MEG3 Promotes Renal Tubular Epithelial Cell Pyroptosis by Regulating the miR-18a-3p/GSDMD Pathway in Lipopolysaccharide-Induced Acute Kidney Injury

Long Non-coding RNA MEG3 Promotes Renal Tubular Epithelial Cell Pyroptosis by Regulating the miR-18a-3p/GSDMD Pathway in Lipopolysaccharide-Induced Acute Kidney Injury

Background and Objective: Acute kidney injury (AKI) is a complication of sepsis. Pyroptosis of gasdermin D (GSDMD)-mediated tubular epithelial cells (TECs) play important roles in pathogenesis of sepsis-associated AKI. Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3), an imprinted gen...

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Bibliographic Details
Main Authors: Junhui Deng, Wei Tan, Qinglin Luo, Lirong Lin, Luquan Zheng, Jurong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Physiology
Subjects:
acute kidney injury
renal tubular epithelial cells
pyroptosis
MEG3
GSDMD
sepsis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.663216/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.663216/full

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