Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice

Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice

Annonaceous acetogenins (ACGs) are one of the most active constituents isolated from Annona species with potent antitumor activity. However, the poor solubility and severe side effect greatly limit their use in clinic. In this study, folic acid (FA) modified annonaceous acetogenins nanosuspensions (...

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Bibliographic Details
Main Authors: Haowen Li, Yijing Li, Hui Ao, Dongdong Bi, Meihua Han, Yifei Guo, Xiangtao Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
annonaceous acetogenins
folate targeting
nanosuspensions
dspe-peg-fa
pegylation
anti-tumor efficiency
Online Access:http://dx.doi.org/10.1080/10717544.2018.1455761

Internet

http://dx.doi.org/10.1080/10717544.2018.1455761

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