Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease

Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease

Mutations in the X-linked gene IQSEC2 are associated with multiple cases of epilepsy, epileptic encephalopathy, intellectual disability and autism spectrum disorder, the mechanistic understanding and successful treatment of which remain a significant challenge in IQSEC2 and related neurodevelopmenta...

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Bibliographic Details
Main Authors: Megha Sah, Amy N. Shore, Sabrina Petri, Ayla Kanber, Mu Yang, Matthew C. Weston, Wayne N. Frankel
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Neurobiology of Disease
Subjects:
IQSEC2
Knockout mouse model
Epileptic encephalopathy
Seizure
Synaptic signaling
Interneurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120300334

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http://www.sciencedirect.com/science/article/pii/S0969996120300334

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