Monitoring the Response of Hyperbilirubinemia in the Mouse Brain by In Vivo Bioluminescence Imaging

Monitoring the Response of Hyperbilirubinemia in the Mouse Brain by In Vivo Bioluminescence Imaging

Increased levels of unconjugated bilirubin are neurotoxic, but the mechanism leading to neurological damage has not been completely elucidated. Innovative strategies of investigation are needed to more precisely define this pathological process. By longitudinal in vivo bioluminescence imaging, we no...

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Bibliographic Details
Main Authors: Isabella Manni, Giuliana Di Rocco, Salvatore Fusco, Lucia Leone, Saviana Antonella Barbati, Carmine Maria Carapella, Claudio Grassi, Giulia Piaggio, Gabriele Toietta
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
bevacizumab
bilirubin
bilirubin-induced neurologic dysfunction
blood–brain barrier
in vivo bioluminescence imaging
hyperbilirubinemia
kernicterus
luciferase
transgenic mice
Online Access:http://www.mdpi.com/1422-0067/18/1/50

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http://www.mdpi.com/1422-0067/18/1/50

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