Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-dependent genetic program to ensure a rapid increase in t...

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Bibliographic Details
Main Authors: Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam, Avinash Bhandoola
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13465-y

Internet

https://doi.org/10.1038/s41467-019-13465-y

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