Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-dependent genetic program to ensure a rapid increase in t...

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Main Authors:	Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam, Avinash Bhandoola
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13465-y

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spelling	doaj-784327815c984356aac217a9fbd2ed1e2021-05-11T11:58:44ZengNature Publishing GroupNature Communications2041-17232019-12-0110111410.1038/s41467-019-13465-yMyc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growthJennifer E. Cowan0Justin Malin1Yongge Zhao2Mina O. Seedhom3Christelle Harly4Izumi Ohigashi5Michael Kelly6Yousuke Takahama7Jonathan W. Yewdell8Maggie Cam9Avinash Bhandoola10Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of HealthDivision of Experimental Immunology, Institute of Advanced Medical Sciences, University of TokushimaSingle Cell Analysis Facility, Center for Cancer Research, National Cancer Institute, National Institutes of HealthExperimental Immunology Branch, National Cancer Institute, National Institutes of HealthLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthOffice of Science and Technology Resources, Office of the Director, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of HealthThymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-dependent genetic program to ensure a rapid increase in thymus size, and thereby expedited T cell generation.https://doi.org/10.1038/s41467-019-13465-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jennifer E. Cowan Justin Malin Yongge Zhao Mina O. Seedhom Christelle Harly Izumi Ohigashi Michael Kelly Yousuke Takahama Jonathan W. Yewdell Maggie Cam Avinash Bhandoola
spellingShingle	Jennifer E. Cowan Justin Malin Yongge Zhao Mina O. Seedhom Christelle Harly Izumi Ohigashi Michael Kelly Yousuke Takahama Jonathan W. Yewdell Maggie Cam Avinash Bhandoola Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth Nature Communications
author_facet	Jennifer E. Cowan Justin Malin Yongge Zhao Mina O. Seedhom Christelle Harly Izumi Ohigashi Michael Kelly Yousuke Takahama Jonathan W. Yewdell Maggie Cam Avinash Bhandoola
author_sort	Jennifer E. Cowan
title	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_short	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_full	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_fullStr	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_full_unstemmed	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_sort	myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-12-01
description	Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-dependent genetic program to ensure a rapid increase in thymus size, and thereby expedited T cell generation.
url	https://doi.org/10.1038/s41467-019-13465-y
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Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

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