Synthesis and Cytotoxic Activity of Chiral Sulfonamides Based on the 2-azabicycloalkane Skeleton

Synthesis and Cytotoxic Activity of Chiral Sulfonamides Based on the 2-azabicycloalkane Skeleton

A series of chiral sulfonamides containing the 2-azabicycloalkane scaffold were prepared from <i>aza</i>-Diels–Alder cycloadducts through their conversion to amines based on 2-azanorbornane or the bridged azepane skeleton, followed by the reaction with sulfonyl chlorides. The cytotoxic a...

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Bibliographic Details
Main Authors: Mahzeiar Samadaei, Matthias Pinter, Daniel Senfter, Sibylle Madlener, Nataliya Rohr-Udilova, Dominika Iwan, Karolina Kamińska, Elżbieta Wojaczyńska, Jacek Wojaczyński, Andrzej Kochel
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
2-azabicycloalkane
chiral sulfonamide
cytotoxic activity
Online Access:https://www.mdpi.com/1420-3049/25/10/2355

Internet

https://www.mdpi.com/1420-3049/25/10/2355

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