Development of amplicon deep sequencing markers and data analysis pipeline for genotyping multi-clonal malaria infections

Development of amplicon deep sequencing markers and data analysis pipeline for genotyping multi-clonal malaria infections

Abstract Background Amplicon deep sequencing permits sensitive detection of minority clones and improves discriminatory power for genotyping multi-clone Plasmodium falciparum infections. New amplicon sequencing and data analysis protocols are needed for genotyping in epidemiological studies and drug...

Full description

Bibliographic Details
Main Authors: Anita Lerch, Cristian Koepfli, Natalie E. Hofmann, Camilla Messerli, Stephen Wilcox, Johanna H. Kattenberg, Inoni Betuela, Liam O’Connor, Ivo Mueller, Ingrid Felger
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Genomics
Subjects:
Plasmodium falciparum
Malaria
Amplicon sequencing
SNP
Haplotype clustering
Multi-clone infections
Online Access:http://link.springer.com/article/10.1186/s12864-017-4260-y

Internet

http://link.springer.com/article/10.1186/s12864-017-4260-y

Similar Items