CXCR5+PD1+ICOS+ Circulating T Follicular Helpers Are Associated With de novo Donor-Specific Antibodies After Renal Transplantation

CXCR5+PD1+ICOS+ Circulating T Follicular Helpers Are Associated With de novo Donor-Specific Antibodies After Renal Transplantation

Donor-specific anti-HLA antibodies (DSAs) are a major risk factor associated with renal allograft outcomes. As a trigger of B cell antibody production, T follicular helper cells (Tfhs) promote DSA appearance. Herein, we evaluated whether circulating Tfhs (cTfhs) are associated with the genesis of an...

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Bibliographic Details
Main Authors: Richard Danger, Mélanie Chesneau, Florent Delbos, Sabine Le Bot, Clarisse Kerleau, Alexis Chenouard, Simon Ville, Nicolas Degauque, Sophie Conchon, Anne Cesbron, Magali Giral, Sophie Brouard
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
renal transplantation
donor-specific antibodies
DSA
circulating T follicular helper lymphocytes
Tfh
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02071/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02071/full

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