Chaperone-based procedure to increase yields of soluble recombinant proteins produced in <it>E. coli</it>

<p>Abstract</p> <p>Background</p> <p>The overproduction of recombinant proteins in host cells often leads to their misfolding and aggregation. Previous attempts to increase the solubility of recombinant proteins by co-overproduction of individual chaperones were only pa...

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Bibliographic Details
Main Authors: Mogk Axel, Tomoyasu Toshifumi, Deuerling Elke, de Marco Ario, Bukau Bernd
Format: Article
Language:English
Published: BMC 2007-06-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/7/32