Oligonucleotide-Peptide Conjugates: Solid-Phase Synthesis under Acidic Conditions and Use in ELISA Assays

Oligonucleotide-Peptide Conjugates: Solid-Phase Synthesis under Acidic Conditions and Use in ELISA Assays

Here we used solid-phase methods to prepare oligonucleotides carrying fibrin/ filaggrin citrullinated peptides. Post-synthetic conjugation protocols were successfully applied for the synthesis of oligonucleotides carrying small peptides. A stepwise protocol using acid treatment for the final deprote...

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Bibliographic Details
Main Authors: Ramon Eritja, Isabel Haro, Morteza Malakoutikhah, Maria José Gómara, Anna Aviñó
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Molecules
Subjects:
oligonucleotide-peptide conjugates
ELISA
solid-phase synthesis
rheumatoid arthritis
epitopes
anti-citrullinated protein/peptide antibodies
ACPA
fibrin
filaggrin
citrullinated peptides
Online Access:http://www.mdpi.com/1420-3049/17/12/13825

Internet

http://www.mdpi.com/1420-3049/17/12/13825

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