Design, Synthesis, Antiviral Evaluation, and SAR Studies of New 1-(Phenylsulfonyl)-1H-Pyrazol−4-yl-Methylaniline Derivatives

Design, Synthesis, Antiviral Evaluation, and SAR Studies of New 1-(Phenylsulfonyl)-1H-Pyrazol−4-yl-Methylaniline Derivatives

A series of N-((3-phenyl-1-(phenylsulfonyl)-1H-pyrazol-4-yl)methyl)anilines 7a-p and 8a-l, structurally related to previously synthesized and tested (N-(1,3-diphenyl-1H-pyrazol-4-yl)methyl)anilines (1a-v), were designed and synthesized. The new derivatives were evaluated in cell-based assays for the...

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Bibliographic Details
Main Authors: Nicoletta Desideri, Rossella Fioravanti, Luca Proietti Monaco, Elena Maria Atzori, Antonio Carta, Ilenia Delogu, Gabriella Collu, Roberta Loddo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Chemistry
Subjects:
1-(phenylsulfonyl)-1H-pyrazole derivatives
antiviral activity
anti-Flavivirus activity
BVDV
RSV
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00214/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00214/full

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