Trehalose-Induced Remodelling of the Human Microbiota Affects Clostridioides difficile Infection Outcome in an In Vitro Colonic Model: A Pilot Study

Trehalose-Induced Remodelling of the Human Microbiota Affects Clostridioides difficile Infection Outcome in an In Vitro Colonic Model: A Pilot Study

Within the human intestinal tract, dietary, microbial- and host-derived compounds are used as signals by many pathogenic organisms, including Clostridioides difficile. Trehalose has been reported to enhance virulence of certain C. difficile ribotypes; however, such variants are widespread and not co...

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Bibliographic Details
Main Authors: Anthony M. Buckley, Ines B. Moura, Norie Arai, William Spittal, Emma Clark, Yoshihiro Nishida, Hannah C. Harris, Karen Bentley, Georgina Davis, Dapeng Wang, Suparna Mitra, Takanobu Higashiyama, Mark H. Wilcox
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Clostridium difficile
trehalose
human microbiota
microbial competition
in vitro gut model
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.670935/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.670935/full

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