Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A

Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A

Abstract Background The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. Previous studies have found that perinatal tissue (umbilical cord, UC; placenta, PL)-derived mesenchymal stem cel...

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Bibliographic Details
Main Authors: Yoon Jeong Choi, Jun Bon Koo, Hee Yeon Kim, Jin Won Seo, Eun Jeong Lee, Woo Ram Kim, Joo Young Cho, Ki Baik Hahm, Sung Pyo Hong, Duk Hwan Kim, Jun-Hwan Yoo
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Stem Cell Research & Therapy
Subjects:
Intestinal fibrosis
Myofibroblasts
Mesenchymal stem cells
Umbilical cord
Placenta
Online Access:http://link.springer.com/article/10.1186/s13287-019-1385-8

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http://link.springer.com/article/10.1186/s13287-019-1385-8

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