Genetic architecture of atherosclerosis dissected by QTL analyses in three F2 intercrosses of apolipoprotein E-null mice on C57BL6/J, DBA/2J and 129S6/SvEvTac backgrounds.

Genetic architecture of atherosclerosis dissected by QTL analyses in three F2 intercrosses of apolipoprotein E-null mice on C57BL6/J, DBA/2J and 129S6/SvEvTac backgrounds.

Quantitative trait locus (QTL) analyses of intercross populations between widely used mouse inbred strains provide a powerful approach for uncovering genetic factors that influence susceptibility to atherosclerosis. Epistatic interactions are common in complex phenotypes and depend on genetic backgr...

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Bibliographic Details
Main Authors: Natalia Makhanova, Andrew P Morgan, Yukako Kayashima, Andrei Makhanov, Sylvia Hiller, Svetlana Zhilicheva, Longquan Xu, Fernando Pardo-Manuel de Villena, Nobuyo Maeda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0182882

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https://doi.org/10.1371/journal.pone.0182882

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