In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes

In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes

Fibroblast activation protein (FAP) is a proline-selective protease that belongs to the S9 family of serine proteases. It is typically highly expressed in the tumor microenvironment (TME) and especially in cancer-associated fibroblasts, the main cell components of the tumor stroma. The exact role of...

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Bibliographic Details
Main Authors: Yentl Van Rymenant, Muhammet Tanc, Roos Van Elzen, An Bracke, Olivier De Wever, Koen Augustyns, Anne-Marie Lambeir, Mark Kockx, Ingrid De Meester, Pieter Van Der Veken
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Chemistry
Subjects:
fibroblast activation protein
activity-based probe
fluorophore
biomarker
histochemistry
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.640566/full

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