Inhibition of Paracoccidioides lutzii Pb01 isocitrate lyase by the natural compound argentilactone and its semi-synthetic derivatives.

Inhibition of Paracoccidioides lutzii Pb01 isocitrate lyase by the natural compound argentilactone and its semi-synthetic derivatives.

The dimorphic fungus Paracoccidioides spp. is responsible for paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America, causing serious public health problems. Adequate treatment of mycotic infections is difficult, since fungi are eukaryotic organisms with a structure and metabol...

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Bibliographic Details
Main Authors: Renata Silva do Prado, Ricardo Justino Alves, Cecília Maria Alves de Oliveira, Lucília Kato, Roosevelt Alves da Silva, Guilherme Oliveira Quintino, Silvio do Desterro Cunha, Célia Maria de Almeida Soares, Maristela Pereira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3994062?pdf=render

Internet

http://europepmc.org/articles/PMC3994062?pdf=render

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