Sleeping ribosomes: Bacterial signaling triggers RaiA mediated persistence to aminoglycosides

Summary: Indole is a molecule proposed to be involved in bacterial signaling. We find that indole secretion is induced by sublethal tobramycin concentrations and increases persistence to aminoglycosides in V. cholerae. Indole transcriptomics showed increased expression of raiA, a ribosome associated...

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Bibliographic Details
Main Authors: Manon Lang, Evelyne Krin, Chloé Korlowski, Odile Sismeiro, Hugo Varet, Jean-Yves Coppée, Didier Mazel, Zeynep Baharoglu
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221010968