Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues.

Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues.

BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much scrutiny and debate. However, B10 is still an attra...

Full description

Bibliographic Details
Main Authors: Tine Glendorf, Louise Knudsen, Carsten E Stidsen, Bo F Hansen, Anne Charlotte Hegelund, Anders R Sørensen, Erica Nishimura, Thomas Kjeldsen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3285154?pdf=render

Internet

http://europepmc.org/articles/PMC3285154?pdf=render

Similar Items