Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues.
BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much scrutiny and debate. However, B10 is still an attra...
Main Authors: | Tine Glendorf, Louise Knudsen, Carsten E Stidsen, Bo F Hansen, Anne Charlotte Hegelund, Anders R Sørensen, Erica Nishimura, Thomas Kjeldsen |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3285154?pdf=render |
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