A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice: Impact of Sex and Age

A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice: Impact of Sex and Age

Investigation of processes that contribute to the maintenance of genomic stability is one crucial factor in the attempt to understand mechanisms that facilitate ageing. The DNA damage response (DDR) and DNA repair mechanisms are crucial to safeguard the integrity of DNA and to prevent accumulation o...

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Bibliographic Details
Main Authors: Nicola Winkelbeiner, Viktoria K. Wandt, Franziska Ebert, Kristina Lossow, Ezgi E. Bankoglu, Maximilian Martin, Aswin Mangerich, Helga Stopper, Julia Bornhorst, Anna P. Kipp, Tanja Schwerdtle
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
maintenance of genomic integrity
ageing
sex
DNA damage
base excision repair (incision activity)
DNA damage response
Online Access:https://www.mdpi.com/1422-0067/21/18/6600

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https://www.mdpi.com/1422-0067/21/18/6600

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