Rodent genetic models of Huntington disease

Huntington disease (HD) is a dominantly inherited human neurodegenerative disorder characterized by motor deficits, cognitive impairment, and psychiatric symptoms leading to inexorable decline and death. Since the identification of the huntingtin gene and the characteristic expanded CAG repeat/polyg...

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Bibliographic Details
Main Authors: Mary Y. Heng, Peter J. Detloff, Roger L. Albin
Format: Article
Language:English
Published: Elsevier 2008-10-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001319