FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Ameliorates DSS-Induced Colitis Against Oxidative Stress by Activating Nrf2/HO-1 Pathway

FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Ameliorates DSS-Induced Colitis Against Oxidative Stress by Activating Nrf2/HO-1 Pathway

Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder of gastro-intestinal tract, lacking effective drug targets and medications. Caffeic acid phenethyl ester (CAPE), a phenolic constituent derived from propolis, has been reported to be a potential therapeutic agent for IBD...

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Bibliographic Details
Main Authors: Yu Mei, Zihao Wang, Yifan Zhang, Ting Wan, Jincheng Xue, Wei He, Yi Luo, Yijun Xu, Xue Bai, Qi Wang, Yujie Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
oxidative stress
nuclear factor erythroid 2-related factor (Nrf2)
reactive oxygen species (ROS)
caffeic acid phenethyl ester (CAPE)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02969/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02969/full

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