Hsp70 modulates immune response in pancreatic cancer through dendritic cells

Hsp70 modulates immune response in pancreatic cancer through dendritic cells

Heat shock protein 70 (Hsp70), a protein chaperone, is known to promote cell survival and tumor progression. However, its role in the tumor microenvironment (TME) is largely unknown. We specifically evaluated Hsp70 in the TME by implanting tumors in wild-type (WT) controls or Hsp70−/- animals, thus...

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Bibliographic Details
Main Authors: Bhuwan Giri, Prateek Sharma, Tejeshwar Jain, Anthony Ferrantella, Utpreksha Vaish, Siddharth Mehra, Bharti Garg, Srikanth Iyer, Vrishketan Sethi, Zoe Malchiodi, Rossana Signorelli, Harrys K.C Jacob, John George, Preeti Sahay, Ejas P. Bava, Rajinder Dawra, Sundaram Ramakrishnan, Ashok Saluja, Vikas Dudeja
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
pancreatic cancer
hsp70
immunotherapy
stroma
dendritic cells
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1976952

Internet

http://dx.doi.org/10.1080/2162402X.2021.1976952

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