Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment

Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that plays a vital role in the signal transduction of cancers. Hsp90 inhibitors are able to inhibit Hsp90 or the complex of Hsp90 and co-chaperones resulting in the degradation of Hsp90-dependent client proteins through the ubiq...

Full description

Bibliographic Details
Main Authors: Yong Li, Dongmei Zhang, Jun Xu, Junmin Shi, Lei Jiang, Nan Yao, Wencai Ye
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512000639