Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning

Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning

Abstract Background Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, with only recombinant human growth hormone (rhGH) being available. Methods...

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Bibliographic Details
Main Authors: Henry Sung-Ching Wong, Ying-Ju Lin, Hsing-Fang Lu, Wen-Ling Liao, Chien-Hsiun Chen, Jer-Yuarn Wu, Wei-Chiao Chang, Fuu-Jen Tsai
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Biomedical Science
Subjects:
Genome-wide association study
Familial short stature
Single-nucleotide polymorphism
Pharmacogenomics
Drug repositioning/repurposing
Online Access:http://link.springer.com/article/10.1186/s12929-019-0581-2

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http://link.springer.com/article/10.1186/s12929-019-0581-2

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