KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions

KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions

Kmt2a and Kmt2b are H3K4 methyltransferases of the Set1/Trithorax class. We have recently shown the importance of Kmt2b for learning and memory. Here, we report that Kmt2a is also important in memory formation. We compare the decrease in H3K4 methylation and de-regulation of gene expression in hippo...

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Bibliographic Details
Main Authors: Cemil Kerimoglu, M. Sadman Sakib, Gaurav Jain, Eva Benito, Susanne Burkhardt, Vincenzo Capece, Lalit Kaurani, Rashi Halder, Roberto Carlos Agís-Balboa, Roman Stilling, Hendrik Urbanke, Andrea Kranz, A. Francis Stewart, Andre Fischer
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
histone methylation
Kmt2a
Mll1
Kmt2b
Mll2
ChIP-seq
RNA-seq
gene expression
hippocampus
memory
Alzheimer’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309038

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http://www.sciencedirect.com/science/article/pii/S2211124717309038

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