Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass

Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass

Abstract Background Acute kidney injury is a severe complication following cardiopulmonary bypass (CPB) and is associated with capillary leakage and microcirculatory perfusion disturbances. CPB-induced thrombin release results in capillary hyperpermeability via activation of protease-activated recep...

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Bibliographic Details
Main Authors: Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Matijs van Meurs, Jill Moser, Jeannette E. Pankras, Nicole N. van der Wel, Hans W. Niessen, Marc G. Vervloet, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer, Charissa E. van den Brom
Format: Article
Language:English
Published: SpringerOpen 2021-06-01
Series:Intensive Care Medicine Experimental
Subjects:
Cardiopulmonary bypass
Microcirculation
Capillary permeability
Acute kidney injury
Renal perfusion
Edema
Online Access:https://doi.org/10.1186/s40635-021-00393-9

Internet

https://doi.org/10.1186/s40635-021-00393-9

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