Development of an antibody fragment that stabilizes GPCR/G-protein complexes

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

The determination of high resolution structures of G protein coupled receptors (GPCRs) in complex with heterotrimeric G proteins is challenging. Here authors develop an antibody fragment, mAB16, which stabilizes GPCR/G-protein complexes and facilitates the application of high resolution cryo-EM.

Bibliographic Details
Main Authors: Shoji Maeda, Antoine Koehl, Hugues Matile, Hongli Hu, Daniel Hilger, Gebhard F. X. Schertler, Aashish Manglik, Georgios Skiniotis, Roger J. P. Dawson, Brian K. Kobilka
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06002-w

Internet

https://doi.org/10.1038/s41467-018-06002-w

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