Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels

Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels

Abstract Ankyrin B (AnkB) is an adaptor and scaffold for motor proteins and various ion channels that is ubiquitously expressed, including in the brain. AnkB has been associated with neurological disorders such as epilepsy and autism spectrum disorder, but understanding of the underlying mechanisms...

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Bibliographic Details
Main Authors: Catherine S. W. Choi, Ivana A. Souza, Juan C. Sanchez-Arias, Gerald W. Zamponi, Laura T. Arbour, Leigh Anne Swayne
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Molecular Brain
Subjects:
Ankyrin B
Cav2.1
CACNA1A
Intracellular pool
Surface localization
Synapse
Online Access:http://link.springer.com/article/10.1186/s13041-019-0494-8

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http://link.springer.com/article/10.1186/s13041-019-0494-8

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