State-of-the-art automated patch clamp devices: Heat activation, action potentials and high throughput in ion channel screening

State-of-the-art automated patch clamp devices: Heat activation, action potentials and high throughput in ion channel screening

Ion channels are essential in a wide range of cellular functions and their malfunction underlies many disease states making them important targets in drug discovery. Diverse automated patch clamp systems with high-throughput capabilities are available for drug screening, but there are limitations in...

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Bibliographic Details
Main Authors: Sonja eStoelzle, Alison eObergrussberger, Andrea eBruggemann, Claudia eHaarmann, Michael eGeorge, Ralf Franz Kettenhofen, Niels eFertig
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Frontiers in Pharmacology
Subjects:
Electrophysiology
Ion Channels
hERG
nAChR
automated patch clamp
Current clamp
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00076/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00076/full

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