Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts

Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts

Tuberous sclerosis complex (TSC) is a genetic disorder that is associated with multiple neurological manifestations. Previously, we demonstrated that Tsc1 loss in cerebellar Purkinje cells (PCs) can cause altered social behavior in mice. Here, we performed detailed transcriptional and translational...

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Bibliographic Details
Main Authors: Jasbir Singh Dalal, Kellen Diamond Winden, Catherine Lourdes Salussolia, Maria Sundberg, Achint Singh, Truc Thanh Pham, Pingzhu Zhou, William T Pu, Meghan T Miller, Mustafa Sahin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
Tuberous Sclerosis
mTOR
FMRP
translation
ribosome
autism
Online Access:https://elifesciences.org/articles/67399

Internet

https://elifesciences.org/articles/67399

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