Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity

Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity

γ-Secretase is a high molecular weight protein complex composed of four subunits, namely, presenilin (PS; 1 or 2), nicastrin, anterior pharynx defective-1 (Aph-1; A or B), and presenilin enhancer-2 (Pen-2), and is responsible for the cleavage of a number of type-1 transmembrane proteins. A fundament...

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Bibliographic Details
Main Authors: Sébastien S. Hébert, Lutgarde Serneels, Tim Dejaegere, Katrien Horré, Michal Dabrowski, Veerle Baert, Wim Annaert, Dieter Hartmann, Bart De Strooper
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Neurobiology of Disease
Subjects:
Regulated intramembrane proteolysis (RIP)
Alzheimer's disease
γ-Secretase
Aph-1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001846

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http://www.sciencedirect.com/science/article/pii/S0969996104001846

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